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Multicenter Study
. 2015 Jan 5;5(1):e007234.
doi: 10.1136/bmjopen-2014-007234.

Protocol of a thyroid cancer longitudinal study (T-CALOS): a prospective, clinical and epidemiological study in Korea

Kyu Eun Lee  1 , Young Joo Park  2 , Belong Cho  3 , Yunji Hwang  4 , June Young Choi  5 , Su-Jin Kim  1 , Hoonsung Choi  6 , Ho-Chun Choi  3 , Ah Reum An  3 , Do Joon Park  2 , Sue K Park  4 , Yeo-Kyu Youn  7
Affiliations
Multicenter Study

Protocol of a thyroid cancer longitudinal study (T-CALOS): a prospective, clinical and epidemiological study in Korea

Kyu Eun Lee et al. BMJ Open. .

Abstract

Introduction: Thyroid cancer incidence in Korea is the highest in the world and has recently increased steeply. However, factors contributing to this sudden increase have not been fully elucidated, and few studies have explored the postoperative prognosis. The Thyroid Cancer Longitudinal Study (T-CALOS) was initiated with three aims: (1) to identify factors predicting quality of life, recurrence, and incidence of other diseases after thyroid cancer treatments; (2) to investigate environmental exposure to radiation, toxicants and molecular factors in relation to tumour aggressiveness; and (3) to evaluate gene-environment interactions that increase thyroid cancer in comparison with healthy participants from a pool of nationwide population-based healthy examinees.

Methods and analysis: T-CALOS enrols patients with incident thyroid cancer from three general hospitals, Seoul National University Hospital, Seoul National University Bundang Hospital and National Medical Center, Korea. The study is an ongoing project expecting to investigate 5000 patients with thyroid cancer up until 2017. Healthy examinees with a normal thyroid confirmed by sonography have been enrolled at the Healthy Examination Center at Seoul National University Hospital. We are also performing individual matching using two nationwide databases that are open to the public. Follow-up information is obtained at patients' clinical visits and by linkage to the national database. For statistical analysis, we will use conditional logistic regression models and a Cox proportional hazard regression model. A number of stratifications and sensitivity analyses will be performed to confirm the results.

Ethics and dissemination: Based on a large sample size, a prospective study design, comprehensive data collection and biobank, T-CALOS has been independently peer-reviewed and approved by the three hospitals and two funding sources (National Research Foundation of Korea and Korean Foundation for Cancer Research). The results of T-CALOS will be published according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria.

Keywords: EPIDEMIOLOGY.

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Figures

Figure 1
Figure 1
Study design and setting for data collection: Thyroid Cancer Longitudinal Study for Prevention and Incidence (T-CALOS).
See this image and copyright information in PMC

References

    1. Pellegriti G, Frasca F, Regalbuto C et al. Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J Cancer Epidemiol 2013;2013:965212 10.1155/2013/965212 - DOI - PMC - PubMed
    1. Ferlay JSI, Ervik M, Dikshit R et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; Secondary GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer, 2013. http://globocan.iarc.fr (accessed 25 May 2014).
    1. Jung KW, Won YJ, Kong HJ et al. Cancer statistics in Korea: incidence, mortality, survival and prevalence in 2010. Cancer Res Treat 2013;45:1–14. 10.4143/crt.2013.45.1.1 - DOI - PMC - PubMed
    1. Park JH, Lee KS, Choi KS. Burden of cancer in Korea during 2000–2020. Cancer Epidemiol 2013;37:353–9. 10.1016/j.canep.2013.03.015 - DOI - PubMed
    1. Li N, Du XL, Reitzel LR et al. Impact of enhanced detection on the increase in thyroid cancer incidence in the United States: review of incidence trends by socioeconomic status within the surveillance, epidemiology, and end results registry, 1980–2008. Thyroid 2013;23:103–10. 10.1089/thy.2012.0392 - DOI - PMC - PubMed

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