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. 2015 Jun;72(2):551-7.
doi: 10.1007/s12013-014-0501-8.

Synthetic miR-145 Mimic Enhances the Cytotoxic Effect of the Antiangiogenic Drug Sunitinib in Glioblastoma

Hongwei Liu  1 , Zhixiong Liu  1 , Bing Jiang  1 , Lei Huo  1 , Jinfang Liu  1 , Jingchen Lu  2
Affiliations

Synthetic miR-145 Mimic Enhances the Cytotoxic Effect of the Antiangiogenic Drug Sunitinib in Glioblastoma

Hongwei Liu et al. Cell Biochem Biophys. 2015 Jun.

Abstract

Although aggressive therapeutic regimen has been applied in the treatment of Glioblastoma (GBM), the prognosis of patients with GBM remains poor. Preclinical studies have demonstrated the efficacy of Suntinib in GBM both in vitro and in vivo. In this study, we showed that the cytotoxicity was enhanced by transfection with miR-145 mimic. In addition, we suggested that the enhanced cytotoxicity of Sunitinib by miR-145 mimic was mediated by inhibition of both P-gp and Bcrp.

Keywords: GBM; Mir-145 mimic; Suntinib.

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