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. 2014 Mar;18(1):105-10.
doi: 10.5717/jenb.2014.18.1.105. Epub 2014 Feb 16.

Endurance exercise training inhibits neointimal formation via enhancement of FOXOs expression in balloon-induced atherosclerosis rat model

Wei Li  1 , Jun Hyun Jeong  1 , Hee Geon Park  1 , Young Ran Lee  1 , Meng Li  1 , Sang Ki Lee  1
Affiliations

Endurance exercise training inhibits neointimal formation via enhancement of FOXOs expression in balloon-induced atherosclerosis rat model

Wei Li et al. J Exerc Nutrition Biochem. 2014 Mar.

Abstract

Purpose: This study investigated the effect of endurance exercise on neointimal formation, endothelial-dependant relaxation and FOXO expression in balloon-induced carotid arteries of rats.

Methods: Male SD(Sprague-Dawley) rats of 8 weeks ages were randomly divided into 3 groups; Sham-operated control (SO, n=10), Balloon-induced control (BIC, n=10), and Balloon-induced exercise (BIE, n=10). Endurance exercise training was performed on treadmill (18 m/min, 0% grade, 60 min/day, 5 days/week, 4 weeks).

Results: Body weight is significantly reduced in BIE compared with BIC. Neointiaml formation in BIC was significantly higher than SO, but it was significantly recovered in BIE compared with BIC. Endothelial-dependent relaxation in BIC was significantly lower than SO, but it was significantly recovered in BIE compared with BIC and expression of FOXO1 and FOXO3a also were significantly increased BIE compared with BIC.

Conclusion: These data suggest that endurance exercise inhibits neointimal formation and endothelial-dependent relaxation via FOXO expression in balloon-induce atherosclerosis rat model.

Keywords: FOXO1; FOXO3a; endothelial dependant relaxation; endurance exercise; neointimal formation.

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Figures

Fig. 1.
Fig. 1.
Endurance exercise inhibited the elevation of body weight in the rats. SO, Sham-operated control; BIC, Balloon-injured control; BIE, Balloon-injured and exercise. Each data showed mean ± S.E.M. (n = 10). * p < .05 vs. SO; #p < .05 vs. BIC.
Fig. 2.
Fig. 2.
Endurance exercise inhibited the neointimal formation in balloon-induced common carotid arteries of rat. A. SO, Sham-operated control. B. BIC, Balloon-injured control. C. BIE, Balloon-injured and exercise. Each data showed mean ± S.E.M. * p < .05 vs. SC; #p < .05 vs. BIC.
Fig. 3.
Fig. 3.
Endurance exercise increased endothelial-dependent relaxation in balloon-induced common carotid arteries of rat. SO, Sham-operated control; BIC, Balloon-injured control; BIE, Balloon-injured and exercise. Each data showed mean ± S.E.M. * p < .05 vs. SO; #p < .05 vs. BIC.
Fig. 4.
Fig. 4.
Endurance exercise increased expression of FOXO1 and FOXO3a in balloon-induced common carotid arteries of rat. SO, Sham-operated control; BIC, Balloon-injured control; BIE, Balloon-injured and exercise. Each data showed mean ± S.E.M. * p < .05 vs. SO; #p < .05 vs. BIC.
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