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Review
. 2014 Dec 16:4:353.
doi: 10.3389/fonc.2014.00353. eCollection 2014.

EMT or EMT-Promoting Transcription Factors, Where to Focus the Light?

Stéphane Ansieau  1 , Guillaume Collin  1 , Louise Hill  1
Affiliations
Review

EMT or EMT-Promoting Transcription Factors, Where to Focus the Light?

Stéphane Ansieau et al. Front Oncol. .
No abstract available

Keywords: EMT; EMT-TFs; EMT-promoting; escape from fail-safe programs; plasticity.

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Figures

Figure 1
Figure 1
As a mother trying to identify which of hers two sons broke the vase, scientists need to precisely determine the contribution of EMT and EMT-TFs in tumor development.
See this image and copyright information in PMC

References

    1. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell (2009) 139:871–90.10.1016/j.cell.2009.11.007 - DOI - PubMed
    1. Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell (2008) 14:818–29.10.1016/j.devcel.2008.05.009 - DOI - PubMed
    1. De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer (2013) 13:97–110.10.1038/nrc3447 - DOI - PubMed
    1. Tran PT, Shroff EH, Burns TF, Thiyagarajan S, Das ST, Zabuawala T, et al. Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. PLoS Genet (2012) 8:e1002650.10.1371/journal.pgen.1002650 - DOI - PMC - PubMed
    1. Dave N, Guaita-Esteruelas S, Gutarra S, Frias A, Beltran M, Peiro S, et al. Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition. J Biol Chem (2011) 286:12024–32.10.1074/jbc.M110.168625 - DOI - PMC - PubMed

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