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. 2015 Feb;36(2):260-6.
doi: 10.1097/MAO.0000000000000544.

Association between saccular function and gait speed: data from the Baltimore Longitudinal Study of Aging

Andrew J Layman  1 , Carol Li, Eleanor Simonsick, Luigi Ferrucci, John P Carey, Yuri Agrawal
Affiliations

Association between saccular function and gait speed: data from the Baltimore Longitudinal Study of Aging

Andrew J Layman et al. Otol Neurotol. 2015 Feb.

Abstract

Objective: To investigate whether otolith function (saccular and utricular) is associated with walking performance.

Study design: Cross-sectional analysis of observational data collected in the Baltimore Longitudinal Study of Aging.

Setting: National Institute on Aging Intramural Research Program Clinical Research Unit at Harbor Hospital, Baltimore, Maryland.

Patients: Community-dwelling participants.

Intervention(s): Cervical and ocular vestibular evoked myogenic potentials (VEMPs) were used to assess saccular and utricular function, respectively.

Main outcome measure(s): Cervical and ocular VEMP latency and amplitude responses and usual, rapid, and narrow (20 cm) gait speed assessed over a 6-m course.

Results: In 314 participants (mean age, 73.1 yr; range, 26-96 yr), cervical VEMP amplitude mediated the association between age and gait speed-particularly narrow walk speed-in both men and women. Cervical VEMP latency had an independent association with gait speed in age-, height-, and weight-adjusted analyses, although the direction of the association differed by sex. Greater cervical VEMP latency was associated with slower usual, rapid, and narrow gait speed in women but faster rapid gait speed in men. Neither the amplitude nor latency of ocular VEMP was associated with gait speed in men or women.

Conclusion: These findings suggest that age-related slowing of gait speed is in part mediated by the decreased magnitude of saccular response associated with age. The sex-related differential association between saccular response latency and gait speed requires further study.

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Figures

Figure 1
Figure 1
Effect of aging on oVEMP latency and amplitude. oVEMP latencies significantly increased only in men (p < 0.05). cVEMP amplitudes decreased significantly for both men and women with age (p < 0.05)
Figure 2
Figure 2
Effect of aging on cVEMP amplitude and latency. cVEMP latency was not significant for either men or women. CVEMP amplitude significantly decreased with age for both men and women (p < 0.05).
Figure 3
Figure 3
Effect of aging on gait speed for three different gait types. Significant associations between age and gait speed were observed for all three gait types (p<0.05).
Figure 4
Figure 4
Effect of cVEMP amplitude and latency on gait speed. cVEMP latency was significant for women across all three gait functions after age-adjustment. In men, only rapid gate was significant. No significant relationships existed for cVEMP amplitude (α = 0.05). Regression lines were fitted over the amplitude and latency ranges measured for each gender.
Figure 5
Figure 5
Effect of oVEMP amplitude and latency on gait speed. No significant relationships existed after adjusting for age (α = 0.05). Regression lines were fitted over the amplitude and latency ranges measured for each gender.
See this image and copyright information in PMC

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