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Review
. 2015 Jan 6;20(1):648-68.
doi: 10.3390/molecules20010648.

Lectins with anti-HIV activity: a review

Ouafae Akkouh  1 , Tzi Bun Ng  2 , Senjam Sunil Singh  3 , Cuiming Yin  4 , Xiuli Dan  5 , Yau Sang Chan  6 , Wenliang Pan  7 , Randy Chi Fai Cheung  8
Affiliations
Review

Lectins with anti-HIV activity: a review

Ouafae Akkouh et al. Molecules. .

Abstract

Lectins including flowering plant lectins, algal lectins, cyanobacterial lectins, actinomycete lectin, worm lectins, and the nonpeptidic lectin mimics pradimicins and benanomicins, exhibit anti-HIV activity. The anti-HIV plant lectins include Artocarpus heterophyllus (jacalin) lectin, concanavalin A, Galanthus nivalis (snowdrop) agglutinin-related lectins, Musa acuminata (banana) lectin, Myrianthus holstii lectin, Narcissus pseudonarcissus lectin, and Urtica diocia agglutinin. The anti-HIV algal lectins comprise Boodlea coacta lectin, Griffithsin, Oscillatoria agardhii agglutinin. The anti-HIV cyanobacterial lectins are cyanovirin-N, scytovirin, Microcystis viridis lectin, and microvirin. Actinohivin is an anti-HIV actinomycete lectin. The anti-HIV worm lectins include Chaetopterus variopedatus polychaete marine worm lectin, Serpula vermicularis sea worm lectin, and C-type lectin Mermaid from nematode (Laxus oneistus). The anti-HIV nonpeptidic lectin mimics comprise pradimicins and benanomicins. Their anti-HIV mechanisms are discussed.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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