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. 2015 Jan;94(1):e211.
doi: 10.1097/MD.0000000000000211.

Bisphenol A and hormone-associated cancers: current progress and perspectives

Hui Gao  1 , Bao-Jun Yang, Nan Li, Li-Min Feng, Xiao-Yu Shi, Wei-Hong Zhao, Si-Jin Liu
Affiliations

Bisphenol A and hormone-associated cancers: current progress and perspectives

Hui Gao et al. Medicine (Baltimore). 2015 Jan.

Abstract

Bisphenol A (BPA), a carbon-based synthetic compound, exhibits hormone-like properties and is present ubiquitously in the environment and in human tissues due to its widespread use and biological accumulation. BPA can mimic estrogen to interact with estrogen receptors α and β, leading to changes in cell proliferation, apoptosis, or migration and thereby, contributing to cancer development and progression. At the genetic level, BPA has been shown to be involved in multiple oncogenic signaling pathways, such as the STAT3, MAPK, and PI3K/AKT pathways. Moreover, BPA may also interact with other steroid receptors (such as androgen receptor) and plays a role in prostate cancer development. This review summarizes the current literature regarding human exposure to BPA, the endocrine-disrupting effects of BPA, and the role of BPA in hormone-associated cancers of the breast, ovary, and prostate.

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Figures

FIGURE 1
FIGURE 1
Schematic illustration of the estrogenic and estrogen-independent pathways by which BPA promotes transformation or carcinogenesis.
See this image and copyright information in PMC

References

    1. Brotons JA, Olea-Serrano MF, Villalobos M, et al. Xenoestrogens released from lacquer coatings in food cans. Environ Health Perspect 1995; 103:608–612. - PMC - PubMed
    1. Olea N, Pulgar R, Perez P, et al. Estrogenicity of resin-based composites and sealants used in dentistry. Environ Health Perspect 1996; 104:298–305. - PMC - PubMed
    1. Sajiki J, Yonekubo J. Leaching of bisphenol A (BPA) to seawater from polycarbonate plastic and its degradation by reactive oxygen species. Chemosphere 2003; 51:55–62. - PubMed
    1. Kawahata H, Ohta H, Inoue M, et al. Endocrine disrupter nonylphenol and bisphenol A contamination in Okinawa and Ishigaki Islands, Japan—within coral reefs and adjacent river mouths. Chemosphere 2004; 55:1519–1527. - PubMed
    1. Routledge EJ, White R, Parker MG, et al. Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ERbeta. J Biol Chem 2000; 275:35986–35993. - PubMed

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