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. 1989 Oct 15;263(2):613-6.
doi: 10.1042/bj2630613.

Defective phosphorylation of a calmodulin-binding protein in cystic-fibrosis submandibular glands

D K Shori  1 , R L Dormer, M C Goodchild, M A McPherson
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Defective phosphorylation of a calmodulin-binding protein in cystic-fibrosis submandibular glands

D K Shori et al. Biochem J. .

Abstract

Calmodulin-binding proteins in fractions purified from human submandibular glands by calmodulin-Sepharose were phosphorylated with [gamma-32P]ATP, in the absence of exogenous protein kinase. The major proteins phosphorylated had molecular masses of 45, 51 and 61 kDa. Phosphorylation was increased by activators of protein kinase C and inhibited by H-7. Phosphorylation of the 61 kDa band was markedly decreased in cystic-fibrosis submandibular glands.

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