Clinical and biochemical manifestations of Cushing's

Abstract

Introduction: Cushing's syndrome is associated with a number of clinical manifestations and co-morbidities which may not resolve even after long-term remission leading to excessive mortality.

Materials and methods: This review summarizes the main manifestations of Cushing's syndrome (active or in remission) with particular focus on data from recently published literature.

Conclusion: Obesity and metabolic alterations, hypertension and cardio/cerebrovascular complications, hypercoagulability/thromboembolism, neuropsychiatric, muscle/skeletal and immune consequences remain the most challenging. Cardiovascular consequences and immunosuppression determine the main causes of death in Cushing's syndrome necessitating early intervention when possible.