Mx GTPases: dynamin-like antiviral machines of innate immunity
- PMID: 25572883
- DOI: 10.1016/j.tim.2014.12.003
Mx GTPases: dynamin-like antiviral machines of innate immunity
Abstract
The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the viral replication cycle. We focus on new structural and functional insights and discuss recent data revealing that human MxA (MX1) provides a safeguard against introduction of avian influenza A viruses (FLUAV) into the human population. The related human MxB (MX2) serves as restriction factor for HIV-1 and other primate lentiviruses.
Keywords: HIV-1; dynamin-like GTPase; influenza; innate immunity; interferon; primate evolution.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Similar articles
-
Oligomerization Requirements for MX2-Mediated Suppression of HIV-1 Infection.J Virol. 2015 Oct 7;90(1):22-32. doi: 10.1128/JVI.02247-15. Print 2016 Jan 1. J Virol. 2015. PMID: 26446602 Free PMC article.
-
Mx GTPases: efficient host defense against viral intruders.Virologie (Montrouge). 2014 Apr 1;18(2):105-116. doi: 10.1684/vir.2014.0564. Virologie (Montrouge). 2014. PMID: 33065874 English.
-
Structural insight into the assembly of human anti-HIV dynamin-like protein MxB/Mx2.Biochem Biophys Res Commun. 2015 Jan 2;456(1):197-201. doi: 10.1016/j.bbrc.2014.11.058. Epub 2014 Nov 22. Biochem Biophys Res Commun. 2015. PMID: 25446123
-
Mx proteins: GTPases involved in the interferon-induced antiviral state.Ciba Found Symp. 1993;176:233-43; discussion 243-7. doi: 10.1002/9780470514450.ch15. Ciba Found Symp. 1993. PMID: 7507812 Review.
-
Interferons, Mx genes, and resistance to influenza virus.Am J Respir Crit Care Med. 1995 Oct;152(4 Pt 2):S67-71. doi: 10.1164/ajrccm/152.4_Pt_2.S67. Am J Respir Crit Care Med. 1995. PMID: 7551417 Review.
Cited by
-
Comparison of the Ability of High and Low Virulence Strains of Non-cytopathic Bovine Viral Diarrhea Virus-1 to Modulate Expression of Interferon Tau Stimulated Genes in Bovine Endometrium.Front Vet Sci. 2021 Apr 9;8:659330. doi: 10.3389/fvets.2021.659330. eCollection 2021. Front Vet Sci. 2021. PMID: 33898551 Free PMC article.
-
Interferon-beta enhances sensitivity to gemcitabine in pancreatic cancer.BMC Cancer. 2020 Sep 23;20(1):913. doi: 10.1186/s12885-020-07420-0. BMC Cancer. 2020. PMID: 32967656 Free PMC article.
-
The Analyses of Cetacean Virus-Responsive Genes Reveal Evolutionary Marks in Mucosal Immunity-Associated Genes.Biochem Genet. 2022 Dec;60(6):2299-2312. doi: 10.1007/s10528-022-10221-8. Epub 2022 Mar 25. Biochem Genet. 2022. PMID: 35334059 Free PMC article.
-
A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV.Elife. 2018 Dec 6;7:e39823. doi: 10.7554/eLife.39823. Elife. 2018. PMID: 30520725 Free PMC article.
-
The Antiviral Activity of Equine Mx1 against Thogoto Virus Is Determined by the Molecular Structure of Its Viral Specificity Region.J Virol. 2023 Feb 28;97(2):e0193822. doi: 10.1128/jvi.01938-22. Epub 2023 Feb 7. J Virol. 2023. PMID: 36749070 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
