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Comment
. 2015 Jan 8;125(2):212-3.
doi: 10.1182/blood-2014-10-606624.

TET2 loss, a rescue of JAK2V617F HSCs

William Vainchenker  1 , Isabelle Plo  1
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TET2 loss, a rescue of JAK2V617F HSCs

William Vainchenker et al. Blood. .
Free article

Abstract

In this issue of Blood, Chen et al and Kameda et al demonstrate that Tet2 loss has 2 effects in Jak2V617F mice: it increases both the severity of the myeloproliferative disorders and the self-renewal properties of the Jak2V617F hematopoietic stem cells (HSCs).

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