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Clinical Trial
. 2014:2014:869250.
doi: 10.1155/2014/869250. Epub 2014 Dec 9.

Effects of glucomannan-enriched, aronia juice-based supplement on cellular antioxidant enzymes and membrane lipid status in subjects with abdominal obesity

Nevena Kardum  1 , Gordana Petrović-Oggiano  1 , Marija Takic  1 , Natalija Glibetić  1 , Manja Zec  1 , Jasmina Debeljak-Martacic  1 , Aleksandra Konić-Ristić  1
Affiliations
Clinical Trial

Effects of glucomannan-enriched, aronia juice-based supplement on cellular antioxidant enzymes and membrane lipid status in subjects with abdominal obesity

Nevena Kardum et al. ScientificWorldJournal. 2014.

Abstract

The aim of this study was to analyze the effects of a 4-week-long consumption of glucomannan-enriched, aronia juice-based supplement on anthropometric parameters, membrane fatty acid profile, and status of antioxidant enzymes in erythrocytes obtained from postmenopausal women with abdominal obesity. Twenty women aged 45-65 with a mean body mass index (BMI) of 36.1 ± 4.4 kg/m(2) and waist circumference of 104.8 ± 10.1 cm were enrolled. Participants were instructed to consume 100 mL of supplement per day as part of their regular diet. A significant increase in the content of n-3 (P < 0.05) polyunsaturated fatty acids in membrane phospholipids was observed, with a marked increase in the level of docosahexaenoic fatty acid (P < 0.05). Accordingly, a decrease in the n-6 and n-3 fatty acids ratio was observed (P < 0.05). The observed effects were accompanied with an increase in glutathione peroxidase activity (P < 0.05). Values for BMI (P < 0.001), waist circumference (P < 0.001), and systolic blood pressure (P < 0.05) were significantly lower after the intervention. The obtained results indicate a positive impact of tested supplement on cellular oxidative damage, blood pressure, and anthropometric indices of obesity.

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Figures

Figure 1
Figure 1
Activities of antioxidant enzymes at the baseline and end point of the study. Data are presented as mean ± SD. GPx = glutathione peroxidase; SOD = superoxide dismutase; CAT = catalase.
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