Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan 7;13(1):202-21.
doi: 10.3390/md13010202.

Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012

Yiwen Hu  1 , Jiahui Chen  2 , Guping Hu  3 , Jianchen Yu  4 , Xun Zhu  5 , Yongcheng Lin  6 , Shengping Chen  7 , Jie Yuan  8
Affiliations

Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012

Yiwen Hu et al. Mar Drugs. .

Abstract

Every year, hundreds of new compounds are discovered from the metabolites of marine organisms. Finding new and useful compounds is one of the crucial drivers for this field of research. Here we describe the statistics of bioactive compounds discovered from marine organisms from 1985 to 2012. This work is based on our database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products. We performed a comprehensive statistical analysis to understand the characteristics of the novel bioactive compounds and detail temporal trends, chemical structures, species distribution, and research progress. We hope this meta-analysis will provide useful information for research into the bioactivity of marine natural products and drug development.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Variation in number of new marine natural products for 1985–2012.
Figure 2
Figure 2
Statistics of bioactivity of new marine natural products by year (* PHVD: Prevention of heart and vascular disease, ** PN/NT: Protection of neurons/neurotoxicity).
Figure 3
Figure 3
Variation in the number and proportion of the eight bioactivity groups by year (* PHVD: Prevention of heart and vascular disease, ** PN/NT: Protection of neurons/neurotoxicity).
Figure 4
Figure 4
The quantity and proportion of bioactive compounds in each category of chemical compounds.
Figure 5
Figure 5
Distribution of multiple bioactive compounds in each category of chemical compounds.
Figure 6
Figure 6
Bioactivities of new marine natural products (* PHVD: Prevention of heart and vascular disease, ** PN/NT: Protection of neurons/neurotoxicity).
Figure 7
Figure 7
Analysis of the bioactive compounds according to their chemical structures and the proportion of different activities in each type of compound (* PHVD: Prevention of heart and vascular disease, ** PN/NT: Protection of neurons/neurotoxicity).
Figure 8
Figure 8
Number of bioactive compounds isolated from the three groups of marine organisms.
Figure 9
Figure 9
The proportion of bioactive compounds from each group of marine organism with proportions indicated in parentheses.
Figure 10
Figure 10
Number and proportion of bioactive/non-bioactive compounds from marine organisms (* PHVD: Prevention of heart and vascular disease, ** PN/NT: Protection of neurons/neurotoxicity).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Newman D.J., Cragg G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 2012;75:311–335. - PMC - PubMed
    1. Molinski T.F., Dalisay D.S., Lievens S.L., Saludes J.P. Drug development from marine natural products. Nat. Rev. Drug Discov. 2009;8:69–85. doi: 10.1038/nrd2487. - DOI - PubMed
    1. Newman D.J., Cragg G.M., Snader K.M. The influence of natural products upon drug discovery. Nat. Prod. Rep. 2000;17:215–234. doi: 10.1039/a902202c. - DOI - PubMed
    1. Newman D.J., Cragg G.M. Advanced preclinical and clinical trials of natural products and related compounds from marine sources. Curr. Med. Chem. 2004;11:1693–1713. doi: 10.2174/0929867043364982. - DOI - PubMed
    1. Leal M.C., Munro M.H., Blunt J.W., Puga J., Jesus B., Calado R., Rosa R., Madeira C. Biogeography and biodiscovery hotspots of macroalgal marine natural products. Nat. Prod. Rep. 2013;30:1380–1390. doi: 10.1039/c3np70057g. - DOI - PubMed

Publication types

Substances