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Comment
. 2015 Jan 8;57(1):1-3.
doi: 10.1016/j.molcel.2014.12.022.

PLEKHM1: a multiprotein adaptor for the endolysosomal system

Moran Rawet-Slobodkin  1 , Zvulun Elazar  2
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Free article
Comment

PLEKHM1: a multiprotein adaptor for the endolysosomal system

Moran Rawet-Slobodkin et al. Mol Cell. .
Free article

Abstract

Two papers by McEwan et al. (McEwan et al., 2015a, 2015b) identify interactions of PLEKHM1 with autophagosome-associated Atg8 proteins and Salmonella typhimurium effector, SifA, linking autophagy and the Salmonella-containing vacuole (SCV) to the endolysosomal Rab7/HOPS-regulated tethering machinery.

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  • PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.
    McEwan DG, Popovic D, Gubas A, Terawaki S, Suzuki H, Stadel D, Coxon FP, Miranda de Stegmann D, Bhogaraju S, Maddi K, Kirchof A, Gatti E, Helfrich MH, Wakatsuki S, Behrends C, Pierre P, Dikic I. McEwan DG, et al. Mol Cell. 2015 Jan 8;57(1):39-54. doi: 10.1016/j.molcel.2014.11.006. Epub 2014 Dec 11. Mol Cell. 2015. PMID: 25498145
  • PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection.
    McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I. McEwan DG, et al. Cell Host Microbe. 2015 Jan 14;17(1):58-71. doi: 10.1016/j.chom.2014.11.011. Epub 2014 Dec 11. Cell Host Microbe. 2015. PMID: 25500191

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