Comment
doi: 10.1016/j.molcel.2014.12.032.
SLX4: not SIMply a nuclease scaffold?
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- PMID: 25574947
- DOI: 10.1016/j.molcel.2014.12.032
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Comment
SLX4: not SIMply a nuclease scaffold?
Mol Cell.
.
Free article
Abstract
In this issue, Guervilly et al. (2015) and Ouyang et al. (2015) identify SUMO-interacting motifs (SIMs) in the SLX4 DNA repair nuclease scaffold protein that promote its functions in genome stability maintenance pathways independently of its ubiquitin-binding properties.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.Mol Cell. 2015 Jan 8;57(1):108-22. doi: 10.1016/j.molcel.2014.11.015. Epub 2014 Dec 18. Mol Cell. 2015. PMID: 25533185 Free PMC article.
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The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome and genome stability.Mol Cell. 2015 Jan 8;57(1):123-37. doi: 10.1016/j.molcel.2014.11.014. Epub 2014 Dec 18. Mol Cell. 2015. PMID: 25533188
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