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Comment
. 2015 Jan 8;16(1):3-4.
doi: 10.1016/j.stem.2014.12.008.

Targeting the cellular origin of organ fibrosis

Johnny Kim  1 , Thomas Braun  2
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Targeting the cellular origin of organ fibrosis

Johnny Kim et al. Cell Stem Cell. .
Free article

Abstract

Organ fibrosis after injury, which can significantly compromise tissue function, is in part due to proliferation of fibroblasts and myofibroblasts of unclear cellular origin. Now in Cell Stem Cell, Kramann et al. (2015) show that perivascular Gli1+ mesenchymal-stem-cell-like cells generate a large fraction of myofibroblasts in disease conditions.

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