Environmentally-defined enhancer populations regulate diversity of tissue-resident macrophages

Michael Bulger¹, James Palis²

Affiliations

¹ Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, Rochester, NY, USA. Electronic address: michael_bulger@urmc.rochester.edu.
² Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, Rochester, NY, USA.

PMID: 25575465
PMCID: PMC4322767
DOI: 10.1016/j.it.2014.12.002

Comment

Environmentally-defined enhancer populations regulate diversity of tissue-resident macrophages

Michael Bulger et al. Trends Immunol. 2015 Feb.

. 2015 Feb;36(2):61-2.

doi: 10.1016/j.it.2014.12.002. Epub 2015 Jan 7.

Authors

Michael Bulger¹, James Palis²

Affiliations

¹ Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, Rochester, NY, USA. Electronic address: michael_bulger@urmc.rochester.edu.
² Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, Rochester, NY, USA.

PMID: 25575465
PMCID: PMC4322767
DOI: 10.1016/j.it.2014.12.002

Abstract

Macrophages represent a class of cells specialized for phagocytosis that occurs in multiple, phenotypically distinct populations throughout the body. Two studies published in Cell demonstrate that these phenotypic differences reflect drastic differences in the populations of enhancers that regulate transcription, and that this epigenomic diversity is, in fact, highly plastic and sensitive to environmental cues.

Keywords: cellular plasticity; enhancers; histone modification; macrophages; transcription factors.

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Comment on

Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment.
Lavin Y, Winter D, Blecher-Gonen R, David E, Keren-Shaul H, Merad M, Jung S, Amit I. Lavin Y, et al. Cell. 2014 Dec 4;159(6):1312-26. doi: 10.1016/j.cell.2014.11.018. Cell. 2014. PMID: 25480296 Free PMC article.
Environment drives selection and function of enhancers controlling tissue-specific macrophage identities.
Gosselin D, Link VM, Romanoski CE, Fonseca GJ, Eichenfield DZ, Spann NJ, Stender JD, Chun HB, Garner H, Geissmann F, Glass CK. Gosselin D, et al. Cell. 2014 Dec 4;159(6):1327-40. doi: 10.1016/j.cell.2014.11.023. Cell. 2014. PMID: 25480297 Free PMC article.

References

1. Lavin, et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell. 2014;159:1312–1326. - PMC - PubMed
1. Gosselin, et al. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell. 2014;159:1327–1340. - PMC - PubMed
1. Davies LC, et al. Tissue-resident macrophages. Nat Immun. 2013;14:986–995. - PMC - PubMed
1. Gautier EL, et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immun. 2012;13:1118–1128. - PMC - PubMed
1. Schulz C, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science. 2012;336:86–90. - PubMed

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Environmentally-defined enhancer populations regulate diversity of tissue-resident macrophages

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Environmentally-defined enhancer populations regulate diversity of tissue-resident macrophages

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