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Case Reports
. 2015 Jul;66(7):545-8.
doi: 10.1007/s00105-014-3567-8.

[Abscopal effect in the treatment of malignant melanoma]

[Article in German]
C Thallinger  1 , G Prager, H Ringl, C Zielinski
Affiliations
Case Reports

[Abscopal effect in the treatment of malignant melanoma]

[Article in German]
C Thallinger et al. Hautarzt. 2015 Jul.

Abstract

Background: The clearance of non-irradiated tumors after localized radiation therapy is known as the abscopal effect.

Case report: In the present case report we initiated a combined therapeutic approach based on sequential administration of ipilimumab plus temozolomide in combination with radiotherapy. The treatment regime was well tolerated and resulted in unusually long disease stabilization and in a complete response of brain and kidney metastases. Thus, it is speculated that the clinical response was the result of an abscopal effect.

Conclusion: The present case report highlights the possible clinical benefit of the abscopal effect in the treatment of malignant melanoma.

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