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. 2015 Jul;14(4):497-506.
doi: 10.1016/j.jcf.2014.12.006. Epub 2015 Jan 7.

Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

William P Sexauer  1 , Anas Hadeh  2 , Pamela A Ohman-Strickland  3 , Robert L Zanni  4 , Laurie Varlotta  5 , Douglas Holsclaw  6 , Stanley Fiel  7 , Gavin R Graff  8 , Arthur Atlas  9 , Dorothy Bisberg  10 , Denis Hadjiliadis  6 , Suzanne H Michel  11 , Daria Mintz  12 , Rebanta Chakraborty  13 , Bridget Marra  4 , Paula Lomas  7 , Tara Ward  14 , Meagen Sassman  15 , Giovanna C Imbesi  6 , Diane M Kitch  8 , Allison M Mallowe  16
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Free article

Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

William P Sexauer et al. J Cyst Fibros. 2015 Jul.
Free article

Abstract

Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown.

Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2 months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF.

Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8 ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function.

Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.

Keywords: Cystic fibrosis; Lung function; Pulmonary function; Vitamin D.

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