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. 1989 Dec 1;264(2):617-20.
doi: 10.1042/bj2640617.

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

R W Bonser  1 , N T Thompson, R W Randall, L G Garland
Affiliations

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

R W Bonser et al. Biochem J. .

Erratum in

  • Biochem J 1990 Feb 1;265(3):932

Abstract

Neutrophils stimulated with formylmethionyl-leucylphenylalanine (fMet-Leu-Phe) in the presence of butanol and ethanol formed phosphatidyl alcohols through a phospholipase D mechanism. The alcohols inhibited phosphatidic acid and diradylglycerol (DRG) formation, but did not block inositol 1, 4, 5-trisphosphate release. fMet-Leu-Phe-stimulated superoxide production was inhibited by alcohol concentrations which blocked DRG formation, whereas opsonized-zymosan-stimulated superoxide production was only partially decreased. These results suggest that phospholipase D activation is functionally linked to superoxide production in the human neutrophil.

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References

    1. J Clin Invest. 1989 Feb;83(2):718-23 - PubMed
    1. J Biol Chem. 1989 Jan 25;264(3):1450-6 - PubMed
    1. Biochem J. 1988 Dec 1;256(2):585-92 - PubMed
    1. Biochem Pharmacol. 1989 May 15;38(10):1543-9 - PubMed
    1. Biochem J. 1989 Jun 15;260(3):909-13 - PubMed