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. 2014:2014:838950.
doi: 10.1155/2014/838950. Epub 2014 Dec 11.

Prognostic value of glioma cancer stem cell isolation in survival of primary glioblastoma patients

Byung Ho Kong  1 , Ju Hyung Moon  2 , Yong-Min Huh  3 , Jin-Kyoung Shim  2 , Ji-Hyun Lee  2 , Eui-Hyun Kim  2 , Jong Hee Chang  2 , Dong-Seok Kim  2 , Yong-Kil Hong  4 , Sun Ho Kim  2 , Su-Jae Lee  5 , Seok-Gu Kang  2
Affiliations

Prognostic value of glioma cancer stem cell isolation in survival of primary glioblastoma patients

Byung Ho Kong et al. Stem Cells Int. 2014.

Abstract

Cancer stem cells (CSCs) have been reported to be critical in the initiation, maintenance, and progression of cancers. The expression of stem cell markers, such as podoplanin (PDPN), CD133, and nestin, may have been correlated with malignant progression. However, the effects of CSCs and stem cell markers on clinical outcomes in cancer patients remain unclear. In this study, we assessed the prognostic roles of glioma CSCs (gCSCs) isolation and stem cell markers in patients with primary glioblastoma (pGBM). A cohort of 39 patients with pGBM was separated into two groups, those positive or negative for gCSCs, and the correlation between gCSC and patient survival was evaluated. We observed significantly different cumulative survival (P = 0.045) when comparing patients positive for gCSCs patients and negative for gCSC. Among the patients positive for gCSCs, we observed no significant differences in survival between those whose gCSCs were each positive or negative for PDPN, CD133, or nestin. This study strongly supports the prognostic value of gCSCs isolation on the survival of patients with pGBM.

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Figures

Figure 1
Figure 1
Kaplan-Meier survival curves of pGBM patients positive and negative for gCSCs (P = 0.045 as calculated by the log-rank test).
See this image and copyright information in PMC

References

    1. Sulman E., Aldape K., Colman H. Brain tumor stem cells. Current Problems in Cancer. 2008;32(3):124–142. doi: 10.1016/j.currproblcancer.2008.02.004. - DOI - PubMed
    1. Kim Y. G., Jeon S., Sin G.-Y., et al. Existence of glioma stroma mesenchymal stemlike cells in Korean glioma specimens. Child's Nervous System. 2013;29(4):549–563. doi: 10.1007/s00381-012-1988-1. - DOI - PubMed
    1. Kong B. H., Shin H.-D., Kim S.-H., Mok H.-S., Shim J.-K., Lee J.-H., Shin H.-J., Huh Y.-M., Kim E.-H., Park E.-K., Chang J. H., Kim D.-S., Hong Y.-K., Kim S. H., Lee S.-J., Kang S.-G. Increased in vivo angiogenic effect of glioma stromal mesenchymal stem-like cells on glioma cancer stem cells from patients with glioblastoma. International Journal of Oncology. 2013;42(5):1754–1762. doi: 10.3892/ijo.2013.1856. - DOI - PubMed
    1. Kwak J., Shin H. J., Kim S. H., et al. Isolation of tumor spheres and mesenchymal stem-like cells from a single primitive neuroectodermal tumor specimen. Child's Nervous System. 2013;29(12):2229–2239. - PubMed
    1. Lim H.-Y., Kim K. M., Kim B. K., Shim J.-K., Lee J.-H., Huh Y.-M., Kim S.-H., Kim E.-H., Park E.-K., Shim K.-W., Chang J. H., Kim D.-S., Kim S. H., Hong Y.-K., Lee S.-J., Kang S.-G. Isolation of mesenchymal stem-like cells in meningioma specimens. International Journal of Oncology. 2013;43(4):1260–1268. doi: 10.3892/ijo.2013.2053. - DOI - PubMed

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