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. 2014:2014:424568.
doi: 10.1155/2014/424568. Epub 2014 Dec 14.

Metastasis of laryngeal squamous cell carcinoma to bilateral thigh muscles

Zarah Lucas  1 , Akash Mukherjee  1 , Stanley Chia  2 , Irina Veytsman  1
Affiliations

Metastasis of laryngeal squamous cell carcinoma to bilateral thigh muscles

Zarah Lucas et al. Case Rep Oncol Med. 2014.

Abstract

Importance. Laryngeal cancer infrequently results in distant metastases, but metastasis to skeletal muscle is extremely uncommon. Observations. A 55-year-old male presenting with progressive dyspnea and hoarseness was found to have Stage IVA T4aN2cM0 laryngeal cancer and eventually underwent total laryngectomy. Before the patient could be started on adjuvant chemoradiation, the patient developed masses on both thighs. Biopsy revealed metastatic squamous cell carcinoma consistent with the primary laryngeal cancer. He was offered palliative chemotherapy; however, he developed new soft tissue masses to the left of his stoma and in the prevertebral area one week later. He also had new cervical and supraclavicular nodes and a pathological compression fracture of L3. Patient died within 4 months of diagnosis. Conclusions. Distant metastasis such as skeletal metastasis portends a poor prognosis. Further studies are required to determine the best course of treatment in these patients.

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Figures

Figure 1
Figure 1
Supraglottic-level CT showing airway narrowed by glottis mass (1) and lymph node metastasis (2).
Figure 2
Figure 2
MRI of bilateral thighs showing contrast-enhancing metastatic skeletal lesions (arrows).
See this image and copyright information in PMC

References

    1. National Cancer Institute Surveillance Epidemiology and End Results SEER Stat Fact Sheet: Larynx, 2014, http://seer.cancer.gov/statfacts/html/laryn.html.
    1. Kulahci Y., Zor F., Onguru O., Bozkurt M., Duman H. Distant muscular (rectus femoris) metastasis from laryngeal squamous cell carcinoma. Journal of Laryngology and Otology. 2009;123(12):1381–1383. doi: 10.1017/S0022215109005544. - DOI - PubMed
    1. Marioni G., Blandamura S., Calgaro N., Ferraro S. M., Stramare R., Staffieri A., De Filippis C. Distant muscular (gluteus maximus muscle) metastasis from laryngeal squamous cell carcinoma. Acta Oto-Laryngologica. 2005;125(6):678–682. doi: 10.1080/00016480410024613. - DOI - PubMed
    1. Yucel E. A., Demirel T., Demiryont M., Egeli U., Deger K. An unusual metastatic site of laryngeal carcinoma: scapular muscles. Journal of Laryngology and Otology. 2003;117(1):85–87. doi: 10.1258/002221503321046757. - DOI - PubMed
    1. Arpaci T., Ugurluer G., Akbas T., Arpaci R. B., Serin M. Imaging of the skeletal muscle metastases. European Review for Medical and Pharmacological Sciences. 2012;16(15):2057–2063. - PubMed

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