Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2015 Apr;61(4):1121-3.
doi: 10.1002/hep.27688. Epub 2015 Mar 10.

Interplay of interleukin-22 and its binding protein in controlling liver scarring

Bin Gao  1
Affiliations
Editorial

Interplay of interleukin-22 and its binding protein in controlling liver scarring

Bin Gao. Hepatology. 2015 Apr.
No abstract available

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Interplay between IL-22 and IL-22BP in regulating liver fibrosis. IL-22, which is produced by immune cells, targets hepatocytes and HSCs by binding to IL-22R1 and IL-10R2. The well-documented hepatoprotective and antifibrotic effects of IL-22 are mediated by the promotion of hepatocyte survival and induction of HSC senescence, respectively. IL-22BP, which lacks both transmembrane and intracellular domains, binds to IL-22 with a 20- to 1,000-fold higher binding affinity than IL-22R1 and subsequently blocks IL-22 activity, thereby exacerbating liver fibrogenesis.
See this image and copyright information in PMC

Comment on

References

    1. Sonnenberg GF, Fouser LA, Artis D. Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat Immunol 2011;12:383–390. - PubMed
    1. Wolk K, Witte E, Witte K, Warszawska K, Sabat R. Biology of interleukin-22. Semin Immunopathol 2010;32:17–31. - PubMed
    1. Rutz S, Eidenschenk C, Ouyang W. IL-22, not simply a Th17 cytokine. Immunol Rev 2013;252:116–132. - PubMed
    1. Radaeva S, Sun R, Pan HN, Hong F, Gao B. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. HEPATOLOGY 2004; 39:1332–1342. - PubMed
    1. Muhl H, Scheiermann P, Bachmann M, Härdle L, Heinrichs A, Pfeilschifter J IL-22 in tissue-protective therapy. Br J Pharmacol 2013; 169:761–771. - PMC - PubMed

LinkOut - more resources