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Comment
. 2015 Apr 6;12(4):1328-9.
doi: 10.1021/mp500382h. Epub 2015 Mar 27.

Comment on "structural determinants of drug partitioning in surrogates of phosphatidylcholine bilayer strata"

William E Acree Jr  1 , Michela Brumfield  1 , Michael H Abraham  2
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Comment

Comment on "structural determinants of drug partitioning in surrogates of phosphatidylcholine bilayer strata"

William E Acree Jr et al. Mol Pharm. .
Free article

Abstract

The Abraham model correlation for describing the partitioning behavior of solutes between water and hexadecane was redetermined using the measured partition coefficient data and solute descriptors derived from experimental data. The newly derived correlation provides a much better mathematical description of the observed partition coefficient data than the correlation given in the published paper.

Keywords: Abraham model; equilibrium; partition coefficients; phosphatidylcholine.

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