Global resource distribution: allocation of actin building blocks by profilin
- PMID: 25584793
- DOI: 10.1016/j.devcel.2014.12.022
Global resource distribution: allocation of actin building blocks by profilin
Abstract
How cells regulate the distribution of a limited pool of actin between two competing structures has long been a mystery. Complementary studies from Suarez et al. (2015) and Rotty et al. (2015) now show that profilin controls the partitioning of actin monomers between competing actin networks assembled by Arp2/3 complex and formins or Ena/VASP.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.Dev Cell. 2015 Jan 12;32(1):54-67. doi: 10.1016/j.devcel.2014.10.026. Epub 2014 Dec 24. Dev Cell. 2015. PMID: 25543281 Free PMC article.
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Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex.Dev Cell. 2015 Jan 12;32(1):43-53. doi: 10.1016/j.devcel.2014.10.027. Epub 2014 Dec 24. Dev Cell. 2015. PMID: 25543282 Free PMC article.
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