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. 2014;11(10):1233-7.
doi: 10.1080/15476286.2014.996054.

Re-editing the paradigm of Cytidine (C) to Uridine (U) RNA editing

Nicolas Fossat  1 , Patrick P L Tam
Affiliations

Re-editing the paradigm of Cytidine (C) to Uridine (U) RNA editing

Nicolas Fossat et al. RNA Biol. 2014.

Abstract

Cytidine (C) to Uridine (U) RNA editing is a post-trancriptional modification that until recently was known to only affect Apolipoprotein b (Apob) RNA and minimally require 2 components of the C to U editosome, the deaminase APOBEC1 and the RNA-binding protein A1CF. Our latest work has identified a novel RNA-binding protein, RBM47, as a core component of the editosome, which can substitute A1CF for the editing of ApoB mRNA. In addition, new RNA species that are subjected to C to U editing have been identified. Here, we highlight these recent discoveries and discuss how they change our view of the composition of the C to U editing machinery and expand our knowledge of the functional attributes of C to U RNA editing.

Keywords: A1CF; APOBEC1; Apolipoprotein b; Intestine; RBM47; RNA editing.

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References

    1. Chen SH, Habib G, Yang CY, Gu ZW, Lee BR, Weng SA, Silberman SR, Cai SJ, Deslypere JP, Rosseneu M, et al. Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon. Science 1987; 238:363-6; PMID:3659919; http://dx.doi.org/ 10.1126/science.3659919 - DOI - PubMed
    1. Powell LM, Wallis SC, Pease RJ, Edwards YH, Knott TJ, Scott J. A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine. Cell 1987; 50:831-40; PMID:3621347; http://dx.doi.org/ 10.1016/0092-8674(87)90510-1 - DOI - PubMed
    1. Teng B, Burant CF, Davidson NO. Molecular cloning of an apolipoprotein B messenger RNA editing protein. Science 1993; 260:1816-9; PMID:8511591; http://dx.doi.org/ 10.1126/science.8511591 - DOI - PubMed
    1. Navaratnam N, Morrison JR, Bhattacharya S, Patel D, Funahashi T, Giannoni F, Teng BB, Davidson NO, Scott J. The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase. J Biol Chem 1993; 268:20709-12; PMID:8407891 - PubMed
    1. Hadjiagapiou C, Giannoni F, Funahashi T, Skarosi SF, Davidson NO. Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein. Nucleic Acids Res 1994; 22:1874-9; PMID:8208612; http://dx.doi.org/ 10.1093/nar/22.10.1874 - DOI - PMC - PubMed

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