Hepatitis C direct antiviral drugs and hepatic decompensation in patients with advanced cirrhosis: culprit or innocent bystander?
- PMID: 25586091
- PMCID: PMC4422509
- DOI: 10.1007/s10620-015-3535-x
Hepatitis C direct antiviral drugs and hepatic decompensation in patients with advanced cirrhosis: culprit or innocent bystander?
Comment on
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Hepatic decompensation likely attributable to simeprevir in patients with advanced cirrhosis.Dig Dis Sci. 2015 Apr;60(4):1031-5. doi: 10.1007/s10620-014-3422-x. Epub 2014 Nov 6. Dig Dis Sci. 2015. PMID: 25373453 Free PMC article.
References
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- Lawitz E, Sulkowski MS, Ghalib R, et al. Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study. Lancet. 2014;384:1756–1765. - PubMed
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- Danan G, Benichou C. Causality assessment of adverse reactions to drugs–I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol. 1993;46:1323–1330. - PubMed
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- Sofosbuvir [package insert] Foster City, CA: Gilead Sciences; 2013.
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- Simeprevir [package insert] Titusville, NJ: Janssen Therapeutics; 2013.
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