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Review
. 2015 Feb 15;349(1-2):10-4.
doi: 10.1016/j.jns.2014.12.035. Epub 2015 Jan 2.

Immunological differences between classical phenothypes of multiple sclerosis

Piotr Iwanowski  1 , Jacek Losy  2
Affiliations
Review

Immunological differences between classical phenothypes of multiple sclerosis

Piotr Iwanowski et al. J Neurol Sci. .

Abstract

Multiple sclerosis (MS), one of the most serious inflammatory and neurodegenerative conditions, is characterized by variable clinical courses - relapsing-remitting (RRMS), primary progressive (PPMS) and secondary progressive (SPMS). Although PPMS affects only 10-15% of the patient population, its course and pathophysiological and immunological background are distinct. In this review we present and discuss main differences between different types of MS, with particular focus on the underlying immunological mechanisms.

Keywords: Adhesion molecules; AntiGM3 antibodies; Demyelination; Neurodegeneration; PPMS; Primary progressive multiple sclerosis.

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