Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Dec 6:3:246.
doi: 10.4103/2277-9175.146366. eCollection 2014.

The Serum and salivary level of malondialdehyde, vitamins A, E, and C in patient with recurrent aphthous stomatitis

Heidar Khademi  1 , Faezeh Khozeimeh  1 , Atefeh Tavangar  1 , Sima Amini  1 , Parichehr Ghalayani  1
Affiliations

The Serum and salivary level of malondialdehyde, vitamins A, E, and C in patient with recurrent aphthous stomatitis

Heidar Khademi et al. Adv Biomed Res. .

Abstract

Background: Oral recurrent aphthous stomatitis (RAS) is a chronic inflammatory disease affected oral mucosa which has afflicted about 20% of the society. Etiology of this disease is unknown. Three main factors influencing aphthous stomatitis are genetic, hematologic, and immunologic factors. Another proposed factor that may be considered in etiology of aphthous ulcer is oxidant, anti-oxidant imbalance in the body. The purpose of this study was the evaluation of lipid peroxide enzyme as an important oxidant agent and anti-oxidant vitamins in the saliva and serum of the patients suffering from RAS and compare it to healthy people.

Materials and methods: In this cross-sectional, descriptive - analytical study, 25 patients suffering from RAS were compared to 24 healthy individuals. Applying enzyme-linked immunosorbent assay method, the amount of malondialdehyde (MDA) as well as Vitamins A, E, and C were measured in the saliva and serum of two groups. The results were analyzed by Statistical Package for the Social Sciences (SPSS) software version (11.5), t-test and χ(2).

Results: No significant difference was detected between salivary and serum levels of antioxidant vitamins (A, E, and C) and MDA in both experimental groups (P > 0.05).

Conclusion: According to the results of this study, RAS is not associated with oxidant-antioxidant imbalance in the body. However, it seems quite necessary to carry out more studies in this area.

Keywords: Lipid peroxidase; malondialdehyde; recurrent aphthous stomatitis; saliva; vitamin.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Minor aphthous ulcer
See this image and copyright information in PMC

References

    1. Woo SB, Greenberg MS. Ulcerative, Vesicular and bullous lesions. In: Green Berg MS, Glick M, Ship J., editors. Burket's Oral Medical, Diagnosis and Treatment. 10th ed. Hamilton: BC Decker; 2008. pp. 57–62.
    1. Ship JA, Chavez EM, Doerr PA, Henson BS, Sarmadi M. Recurrent aphthous stomatitis. Quintessence Int. 2000;31:95–112. - PubMed
    1. Porter SR, Scully C, Pedersen A. Recurrent aphthous stomatitis. Crit Rev Oral Biol Med. 1998;9:306–21. - PubMed
    1. Scully C, Gorsky M, Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis: A consensus approach. J Am Dent Assoc. 2003;134:200–7. - PubMed
    1. Hoelzl C, Bichler J, Ferk F, Simic T, Nersesyan A, Elbling L, et al. Methods for the detection of antioxidants which prevent age related diseases: A critical review with particular emphasis on human intervention studies. J Physiol Pharmacol. 2005;56:49–64. - PubMed