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Editorial
. 2015;14(4):467-8.
doi: 10.1080/15384101.2015.1006543.

Longevity through DNA damage tolerance

Laia Castells-Roca  1 , Michael M Mueller, Björn Schumacher
Affiliations
Editorial

Longevity through DNA damage tolerance

Laia Castells-Roca et al. Cell Cycle. 2015.
No abstract available

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Figures

Figure 1.
Figure 1.
In response to DNA damage the FOXO transcription factor DAF-16 translocates into the nucleus where it interacts with the GATA transcription factor EGL-27 to induce developmental growth genes that allow the growth of somatic tissues even in the presence of persistent DNA damage. In adult animals, DAF-16 enhances the maintenance of tissue functionality to withstand persistent DNA damage. However, as worms age DAF-16 responsiveness to DNA damage declines rendering the somatic tissues increasingly defenseless against the accumulating DNA damage with aging.
See this image and copyright information in PMC

Comment on

  • doi: 10.1038/ncb3071

References

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