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Review
. 2015 Mar:39:91-6.
doi: 10.1016/j.semcdb.2014.12.007. Epub 2015 Jan 12.

Survivin - The inconvenient IAP

Dario C Altieri  1
Affiliations
Review

Survivin - The inconvenient IAP

Dario C Altieri. Semin Cell Dev Biol. 2015 Mar.

Abstract

Although technically a member of the Inhibitor of Apoptosis (IAP) gene family, survivin has consistently defied assumptions, refuted predictions and challenged paradigms. Despite its more than 5500 citations currently in Medline, the biology of survivin has remained fascinatingly complex, its exploitation in human disease, most notably cancer, tantalizing, and its regulation of cellular homeostasis unexpectedly far-reaching. An inconvenient outsider that resists schemes and dogmas, survivin continues to hold great promise to unlock fundamental circuitries of cellular functions in health and disease.

Keywords: Apoptosis; Cancer; Cell division; IAP; Mitotic catastrophe; Survivin.

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Figures

Figure 1
Figure 1. Post-translational modifications in survivin
Amino acids undergoing Ser/Thr phosphorylation, acetylation or ubiquitylation are indicated. The positions of the proposed dimer interface and nuclear export sequence (NES) are shown.
Figure 2
Figure 2. Tripartite role of survivin at mitosis
A proposed role of survivin in inhibiting apoptosis/mitotic catastrophe (i), regulating spindle assembly (ii) and CPC targeting for a centromere checkpoint (iii) are indicated. See text for additional details.
See this image and copyright information in PMC

References

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