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. 2015 Sep;15(9):709-15.
doi: 10.5152/akd.2014.5470. Epub 2015 Jan 7.

Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani population

Syed Kashif Nawaz  1 , Aasma Noreen, Asima Rani, Memoona Yousaf, Muhammad Arshad
Affiliations

Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani population

Syed Kashif Nawaz et al. Anatol J Cardiol. 2015 Sep.

Abstract

Objective: The present study aimed to investigate the association between the rs10757274 SNP (present on locus 9p21 in the gene for CDKN2B-AS1) and coronary artery disease (CAD) in a local population of Pakistan.

Methods: It was a case-control study. An allele-specific PCR-based strategy was used for the identification of genotypes. A total of 350 samples were used for the investigation, out of which 220 samples were CAD patients and 130 samples were normal healthy individuals. Effects of parameters, like family history of CAD, smoking, presence of diabetes, and hypertension, in changing the chances of CAD were studied. Odds ratio was estimated with 95% confidence interval.

Results: A strong association was observed between CAD and factors, like smoking (OR: 1.666; 95% CI: 1.042-2.664), presence of hypertension (OR: 26.55; 95% CI: 15.95-44.20), diabetes (OR: 3.009; 95% CI: 1.841-4.920), and family history of CAD (OR: 4.9; 95% CI: 2.965-8.099). Results for the association between the genotype on the basis of rs10757274 showed a strong association between the GG genotype and the occurrence of CAD (OR: 9.603; 95% CI: 5.746-16.05).

Conclusion: The present results suggest the importance of the 9p21 locus in modulating the chances of CAD.

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Conflict of interest statement

Conflict of interest: None declared.

References

    1. Slack J, Evans KA. The increased risk of death from ischaemic heart disease in first degree relatives of 121 men and 96 women with ischaemic heart disease. J Med Genet. 1966;3:239–7. [CrossRef] - PMC - PubMed
    1. Levy S, Sutton G, Ng PC, Feuk L, Halpern AL, Walenz BP, et al. The diploid genome sequence of an individual human. PLoS Biol. 2007;5:E254. [CrossRef] - PMC - PubMed
    1. Wheeler DA, Srinivasan M, Egholm M, Shen Y, Chen L, McGuire A, et al. The complete genome of an individual by massively parallel DNA sequencing. Nature. 2008;452:872–6. [CrossRef] - PubMed
    1. Peyser PA, Bielak LF, Chu JS, Turner ST, Ellsworth DL, Boerwinkle E, et al. Heritability of coronary artery calcium quantity measured by electron beam computed tomography in asymptomatic adults. Circulation. 2002;106:304–8. [CrossRef] - PubMed
    1. Goldstein JL, Brown MS. Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. Proc Natl Acad Sci USA. 1973;70:2804–8. [CrossRef] - PMC - PubMed

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