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Review
. 2015 Jan 15;517(7534):311-20.
doi: 10.1038/nature14191.

Necroptosis and its role in inflammation

Manolis Pasparakis  1 , Peter Vandenabeele  2
Affiliations
Review

Necroptosis and its role in inflammation

Manolis Pasparakis et al. Nature. .

Abstract

Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires the proteins RIPK3 and MLKL and is induced by death receptors, interferons, toll-like receptors, intracellular RNA and DNA sensors, and probably other mediators. RIPK1 has important kinase-dependent and scaffolding functions that inhibit or trigger necroptosis and apoptosis. Mouse-model studies have revealed important functions for necroptosis in inflammation and suggested that it could be implicated in the pathogenesis of many human inflammatory diseases. We discuss the mechanisms regulating necroptosis and its potential role in inflammation and disease.

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References

    1. Elife. 2014 Dec 02;3:null - PubMed
    1. Immunity. 2011 Mar 25;34(3):340-51 - PubMed
    1. Science. 2014 Mar 21;343 (6177):1357-60 - PubMed
    1. Nature. 2007 Mar 29;446(7135):557-61 - PubMed
    1. Cell. 2009 Jun 12;137(6):1112-23 - PubMed

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