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Review
. 2015 Feb;15(2):81-95.
doi: 10.1038/nrc3877. Epub 2015 Jan 16.

The RUNX family: developmental regulators in cancer

Yoshiaki Ito  1 , Suk-Chul Bae  2 , Linda Shyue Huey Chuang  1
Affiliations
Review

The RUNX family: developmental regulators in cancer

Yoshiaki Ito et al. Nat Rev Cancer. 2015 Feb.

Abstract

RUNX proteins belong to a family of metazoan transcription factors that serve as master regulators of development. They are frequently deregulated in human cancers, indicating a prominent and, at times, paradoxical role in cancer pathogenesis. The contextual cues that direct RUNX function represent a fast-growing field in cancer research and could provide insights that are applicable to early cancer detection and treatment. This Review describes how RUNX proteins communicate with key signalling pathways during the multistep progression to malignancy; in particular, we highlight the emerging partnership of RUNX with p53 in cancer suppression.

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References

    1. Nat Genet. 2002 Sep;32(1):206-10 - PubMed
    1. J Biol Chem. 2004 Jul 9;279(28):29409-17 - PubMed
    1. Cell Rep. 2014 Jul 10;8(1):50-8 - PubMed
    1. Science. 1990 Nov 30;250(4985):1233-8 - PubMed
    1. Nat Rev Cancer. 2012 Jun 22;12(7):465-77 - PubMed

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