Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Jan 16;116(2):235-6.
doi: 10.1161/CIRCRESAHA.114.305490.

Dawn of the Epi-LncRNAs: new path from Myheart

Zhihua Wang  1 , Yibin Wang  2
Affiliations
Comment

Dawn of the Epi-LncRNAs: new path from Myheart

Zhihua Wang et al. Circ Res. .

Abstract

Myheart is a cardiac specific long-noncoding (lnc) RNA with targeted modulation of chromatin modifying SWI/SNF complex via direct interaction with Brg1. Genetic induction of Myheart in mouse heart has a significant protective effect against the pathogenesis of heart failure. LncRNAs are emerging epigenetic regulators with potentially important roles in cardiac development and diseases.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Epigenetic regulations by long non-coding RNAs (lncRNAs)
Regulatory circuit of α- and β-myosin heavy chain (Myh6 and Myh7) involving diverse epigenetic regulators.
See this image and copyright information in PMC

Comment on

  • A long noncoding RNA protects the heart from pathological hypertrophy.
    Han P, Li W, Lin CH, Yang J, Shang C, Nuernberg ST, Jin KK, Xu W, Lin CY, Lin CJ, Xiong Y, Chien H, Zhou B, Ashley E, Bernstein D, Chen PS, Chen HV, Quertermous T, Chang CP. Han P, et al. Nature. 2014 Oct 2;514(7520):102-106. doi: 10.1038/nature13596. Epub 2014 Aug 10. Nature. 2014. PMID: 25119045 Free PMC article.

References

    1. Bonasio R, Shiekhattar R. Regulation of transcription by long noncoding rnas. Annual review of genetics. 2014;48:433–455. - PMC - PubMed
    1. Wang K, Liu F, Zhou LY, Long B, Yuan SM, Wang Y, Liu CY, Sun T, Zhang XJ, Li PF. The long noncoding rna chrf regulates cardiac hypertrophy by targeting mir-489. Circulation research. 2014;114:1377–1388. - PubMed
    1. Han P, Li W, Lin CH, Yang J, Shang C, Nurnberg ST, Jin KK, Xu W, Lin CY, Lin CJ, Xiong Y, Chien HC, Zhou B, Ashley E, Bernstein D, Chen PS, Chen HS, Quertermous T, Chang CP. A long noncoding rna protects the heart from pathological hypertrophy. Nature. 2014;514:102–106. - PMC - PubMed
    1. Olson EN. Gene regulatory networks in the evolution and development of the heart. Science. 2006;313:1922–1927. - PMC - PubMed
    1. McKinsey TA, Olson EN. Cardiac hypertrophy: Sorting out the circuitry. Current opinion in genetics & development. 1999;9:267–274. - PubMed

Publication types