Platelet GPIb: sensing force and responding
- PMID: 25593332
- PMCID: PMC4296005
- DOI: 10.1182/blood-2014-12-610642
Platelet GPIb: sensing force and responding
Abstract
In this issue of Blood, Zhang and colleagues identify a structural motif in the α-subunit of the membrane glycoprotein (GP)Ib-IX-V complex that may explain how platelets sense mechanical force while responding to vascular injury.
Conflict of interest statement
Conflict-of-interest disclosure: The author declares no competing financial interests.
Comment on
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Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex.Blood. 2015 Jan 15;125(3):562-9. doi: 10.1182/blood-2014-07-589507. Epub 2014 Oct 30. Blood. 2015. PMID: 25359992 Free PMC article.
References
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- Mazzucato M, Pradella P, Cozzi MR, De Marco L, Ruggeri ZM. Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ibalpha mechanoreceptor. Blood. 2002;100(8):2793–2800. - PubMed
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