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. 1989 Dec 15;107(1-3):125-8.
doi: 10.1016/0304-3940(89)90803-3.

Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen

N A Lambert  1 , N L Harrison, D I Kerr, J Ong, R H Prager, T J Teyler
Affiliations

Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen

N A Lambert et al. Neurosci Lett. .

Abstract

The effects of the GABAB receptor antagonist 2-hydroxy-saclofen were studied using intracellular recording of synaptic potential from CA1 hippocampal neurons. 2-Hydroxy-saclofen (50-200 microM) reversibly blocked the late, GABAB receptor-mediated inhibitory postsynaptic potential (IPSP) but not the early, GABAA receptor-mediated IPSP. In addition, the hyperpolarizing response to baclofen was reduced by similar concentrations of 2-hydroxy-saclofen. This suggests that 2-hydroxy-saclofen is a potent antagonist at postsynaptic GABAB receptors on hippocampal neurons.

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