Disentangling inborn and acquired immunity in human twins

Jean-Laurent Casanova¹, Laurent Abel²

Affiliations

¹ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, Paris, France; Paris Descartes University, Imagine Institute, Paris, France; Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, Paris, France. Electronic address: casanova@rockefeller.edu.
² St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, Paris, France; Paris Descartes University, Imagine Institute, Paris, France.

PMID: 25594170
DOI: 10.1016/j.cell.2014.12.029

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Disentangling inborn and acquired immunity in human twins

Jean-Laurent Casanova et al. Cell. 2015.

Free article

. 2015 Jan 15;160(1-2):13-5.

doi: 10.1016/j.cell.2014.12.029.

Authors

Jean-Laurent Casanova¹, Laurent Abel²

Affiliations

¹ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, Paris, France; Paris Descartes University, Imagine Institute, Paris, France; Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, Paris, France. Electronic address: casanova@rockefeller.edu.
² St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, Paris, France; Paris Descartes University, Imagine Institute, Paris, France.

PMID: 25594170
DOI: 10.1016/j.cell.2014.12.029

Abstract

The human geneticist Archibald Garrod noted in 1931 that, "It is, of necessity, no easy matter to distinguish between immunity which is inborn and that which has been acquired" (The Inborn Factors in Disease). In this issue of Cell, Brodin et al. show that the heritability of blood counts rapidly decreases with age for the lymphoid subsets responsible for adaptive immunity, unlike cells from other hematopoietic lineages.

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Variation in the human immune system is largely driven by non-heritable influences.
Brodin P, Jojic V, Gao T, Bhattacharya S, Angel CJ, Furman D, Shen-Orr S, Dekker CL, Swan GE, Butte AJ, Maecker HT, Davis MM. Brodin P, et al. Cell. 2015 Jan 15;160(1-2):37-47. doi: 10.1016/j.cell.2014.12.020. Cell. 2015. PMID: 25594173 Free PMC article.

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Disentangling inborn and acquired immunity in human twins

Affiliations

Disentangling inborn and acquired immunity in human twins

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Abstract

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