A protein restriction-dependent sulfur code for longevity

Hong Seok Shim¹, Valter D Longo²

Affiliations

¹ Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA.
² Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA; Longevity Institute, Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy. Electronic address: vlongo@usc.edu.

PMID: 25594171
DOI: 10.1016/j.cell.2014.12.027

Free article

Comment

A protein restriction-dependent sulfur code for longevity

Hong Seok Shim et al. Cell. 2015.

Free article

. 2015 Jan 15;160(1-2):15-7.

doi: 10.1016/j.cell.2014.12.027.

Authors

Hong Seok Shim¹, Valter D Longo²

Affiliations

¹ Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA.
² Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA; Longevity Institute, Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy. Electronic address: vlongo@usc.edu.

PMID: 25594171
DOI: 10.1016/j.cell.2014.12.027

Abstract

The restriction of proteins has recently emerged as the most important factor for the beneficial effects of calorie restriction. Hine et al. now provide strong evidence for the role of the hydrogen sulfide (H2S) gas in the protective effects of calorie and protein restriction against ischemia/reperfusion injury (IRI) but also implicate H2S in longevity extension in model organisms.

PubMed Disclaimer

Comment on

Endogenous hydrogen sulfide production is essential for dietary restriction benefits.
Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L, Longchamp A, Treviño-Villarreal JH, Mejia P, Ozaki CK, Wang R, Gladyshev VN, Madeo F, Mair WB, Mitchell JR. Hine C, et al. Cell. 2015 Jan 15;160(1-2):132-44. doi: 10.1016/j.cell.2014.11.048. Epub 2014 Dec 23. Cell. 2015. PMID: 25542313 Free PMC article.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A protein restriction-dependent sulfur code for longevity

Affiliations

A protein restriction-dependent sulfur code for longevity

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources