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. 2015 Jan 15:278:1-10.
doi: 10.1016/j.jneuroim.2014.11.022. Epub 2014 Nov 27.

Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies

Susana Brun  1 , Wissam Beaino  2 , Laurent Kremer  1 , Omar Taleb  1 , Ayikoe Guy Mensah-Nyagan  1 , Chanh D Lam  1 , Judith M Greer  3 , Jérôme de Seze  1 , Elisabeth Trifilieff  4
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Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies

Susana Brun et al. J Neuroimmunol. .

Abstract

Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180-199) peptide developed a chronic, sometimes relapsing-remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17(+) cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies.

Keywords: Animal model; CIDP; Chronic EAN; Electrophysiology; Immunology; Sciatic nerve immunohistochemistry; Thiopalmitoylated P0 peptide.

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