Chronic systemic IL-1β exacerbates central neuroinflammation independently of the blood-brain barrier integrity

Abstract

Peripheral circulating cytokines are involved in immune to brain communication and systemic inflammation is considered a risk factor for flaring up the symptoms in most neurodegenerative diseases. We induced both central inflammatory demyelinating lesion, and systemic inflammation with an interleukin-1β expressing adenovector. The peripheral pro-inflammatory stimulus aggravated the ongoing central lesion independently of the blood-brain barrier (BBB) integrity. This model allows studying the role of specific molecules and cells (neutrophils) from the innate immune system, in the relationship between central and peripheral communication, and on relapsing episodes of demyelinating lesions, along with the role of BBB integrity.

Keywords: Blood–brain barrier; Interleukin-1β; Multiple sclerosis; Neuroinflammation; Neutrophils; Systemic inflammation.