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. 2015 Jan 15:278:53-9.
doi: 10.1016/j.jneuroim.2014.12.005. Epub 2014 Dec 5.

A clinical and laboratory study evaluating the profile of cytokine levels in relapsing remitting and secondary progressive multiple sclerosis

Livia Pasquali  1 , Cinzia Lucchesi  2 , Chiara Pecori  2 , Maria Rita Metelli  3 , Silvia Pellegrini  4 , Alfonso Iudice  2 , Ubaldo Bonuccelli  2
Affiliations

A clinical and laboratory study evaluating the profile of cytokine levels in relapsing remitting and secondary progressive multiple sclerosis

Livia Pasquali et al. J Neuroimmunol. .

Abstract

The main aim of the study was to evaluate levels of cytokines IL-1ra, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, TNF-alfa, TGB-beta1 and IFN-gamma in 30 patients with relapsing remitting (RRMS) compared to 30 secondary progressive multiple sclerosis (SPMS) in a peripheral blood sample. Statistical analysis showed significant higher levels of IL-17 and INF-gamma, which are cytokines with pro-inflammatory properties, and lower levels of TGF-beta1, a molecule with immunosuppressant activity, in RRMS compared to SPMS. These results underline the existence of a different cytokines dysregulation in RRMS compared to SPMS phases with higher pro-inflammatory activity in RRMS.

Keywords: Cytokines; IL-17; INF-gamma; Relapsing remitting multiple sclerosis; Secondary progressive multiple sclerosis; TGF-beta.

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