Cell death. Silencing the immune response of apoptotic cells

Comment

Kirsty Minton. Nat Rev Immunol. 2015 Feb.

. 2015 Feb;15(2):68-9.

doi: 10.1038/nri3808. Epub 2015 Jan 19.

Abstract

Mitochondrial DNA released during apoptosis triggers a type I interferon response that is held in check by the apoptotic caspases.

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.
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Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.
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