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. 2015;22(1):35-42.
doi: 10.3109/09687637.2014.970515.

Associations between prescription opioid injection and Hepatitis C virus among young injection drug users

Stephen E Lankenau  1 , Aleksandar Kecojevic  2 , Karol Silva  3
Affiliations

Associations between prescription opioid injection and Hepatitis C virus among young injection drug users

Stephen E Lankenau et al. Drugs (Abingdon Engl). 2015.

Abstract

Objective: Hepatitis C virus (HCV) incidence has been increasing among young injection drug users (IDUs). This analysis examined whether the emerging practice of prescription opioid (PO) injection is associated with self-reported HCV among young IDUs.

Methods: Young IDUs (n = 162) aged 18-25-years-old who indicated recent misuse of prescription drugs were sampled in New York and Los Angeles during 2009-2011. Participants reported lifetime PO injection history and results from their most recent HCV test as well as demographic characteristics and lifetime drug use. Bivariate analyses examined relationships between covariates and both lifetime PO injection and HCV positivity. Poisson regression examined the associations between lifetime PO injection, HCV positivity, and significant covariates.

Results: A majority reported lifetime PO injection (72.2%) and 30.9% self-reported being HCV positive. Lifetime PO injectors were nearly three times more likely to report being HCV positive than non-PO injectors (adjusted incidence rate ratio (AIRR): 2.69, p<0.05) after controlling for socio-demographic and other drug use variable. Additionally, substituting POs for heroin (AIRR: 2.27, p<0.05), growing up in a lower social class (AIRR: 1.67, p<0.05), age (AIRR: 1.12, p<0.05), age of injection initiation (AIRR: 0.87, p<0.001), and history of being prescribed stimulants (AIRR: 0.64, p<0.05) were independently associated with HCV positivity.

Conclusions: Findings suggest that PO injection should be given further consideration as a contributing factor to rising HCV infection among young adults in the US.

Keywords: Hepatitis C virus; injection drug use; opiates.

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Conflict of interest statement

Declaration of interest

This research was supported by funding from the National Institute on Drug Use (R01 DA021299). NIDA had no role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication. There are no conflicts of interest to report.

References

    1. Alter MJ, Gerety RJ, Smallwood L, Sampliner RE, Tabor E, Deinhardt F, Matanoski GM. Sporadic non-A, non-B hepatitis: Frequency and epidemiology in an urban U.S. population. The Journal of Infectious Diseases. 1982;145:886–893. - PubMed
    1. Barros AJ, Hirakata VN. Alternatives for logistic regression in cross-sectional studies: An empirical comparisson of models that directly estimate the prevalence ratio. BMC Medical Research Methodology. 2003;3:21. - PMC - PubMed
    1. Bell J, Batey RG, Farrell GC, Crewe EB, Cunningham AL, Byth K. Hepatitis C virus in intravenous drug users. The Medical Journal of Australia. 1990;153:274–276. - PubMed
    1. Biernacki P, Waldorf D. Snowball sampling: Problems, techniques and chain-referral sampling. Sociological Methods and Research. 1981;10:141–163.
    1. Black RA, Trudeau KJ, Cassidy TA, Budman SH, Butler SF. Associations between public health indicators and injecting prescription opioids by prescription opioid abusers in substance abuse treatment. Journal of Opioid Management. 2013;9:5–17. - PubMed

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