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. 2015;14(1):27-32.
doi: 10.1007/s12522-014-0192-2. Epub 2014 Aug 21.

Acceptable pregnancy rate of unstimulated intrauterine insemination: a retrospective analysis of 17,830 cycles

Tetsuro Honda  1 , Mai Tsutsumi  1 , Fumio Komoda  1 , Kenichi Tatsumi  1
Affiliations

Acceptable pregnancy rate of unstimulated intrauterine insemination: a retrospective analysis of 17,830 cycles

Tetsuro Honda et al. Reprod Med Biol. 2015.

Abstract

Purpose: To evaluate the pregnancy rate (PR) of unstimulated intrauterine insemination (IUI).

Methods: This was a retrospective study in a private fertility clinic. Between 2004 and 2013, a total of 4,045 women underwent 17,830 cycles of unstimulated IUI. The etiologies of subfertility in the couples were unexplained (51 %), male factor (36 %), coital problems (9.5 %), and cervical factor (3.5 %).

Results: The PRs/cycle, between the 1st and 9th trials, in women <35, 35-37, 38-40, 41-42, and >42 years of age were 8.2, 7.3, 5.5, 3.6, and 0.9 %, respectively. In 10,076 cycles in which the male partner had a total motile sperm count ≥5 million, the PRs in the respective age groups were 9.9, 8.6, 6.1, 4.8, and 1.2 %. The largest-sized reported PRs for clomiphene citrate (CC)/IUI in the respective age groups were 11.5, 9.2, 7.3 4.3, and 1.0 % (4,199 cycles in total, Dovey et al., FertilSteril, 2008;90:2281-2286). There were no significant differences in PRs between unstimulated IUI and CC/IUI.

Conclusion: PR for unstimulated IUI was similar to the reported PR for CC/IUI. Although this was a retrospective study without a control group, to reduce multiple pregnancy rate, we believe that unstimulated IUI is a reasonable treatment.

Keywords: Controlled ovarian hyperstimulation; Intrauterine insemination; Multiple pregnancy; Pregnancy rate; Unstimulated.

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Conflict of interest statement

All the authors state explicitly that there are no conflicts of interest in connection with this article.

Figures

Figure 1
Figure 1
Pregnancy rate (PR) and live birth rate (LBR) per trial cycle in women at <35 (a), 35–37 (b), 38–40(c), 41–42 (d), and >42 years of age (e)
Figure 2
Figure 2
The relation between pregnancy rate (PR) and the number of trial cycle in women at < 35 (a), 35–37 (b), 38–40 (c), 41–42 (d), and > 42 years of age (e)
Figure 3
Figure 3
a Cumulative live birth rate (LBR) and b the number of patients in each trial by age group
See this image and copyright information in PMC

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