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. 2015 Mar;11(3):195-7.
doi: 10.1038/nchembio.1734. Epub 2015 Jan 19.

The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine

Stéphane Cociancich  1 , Alexander Pesic  2 , Daniel Petras  2 , Stefanie Uhlmann  2 , Julian Kretz  2 , Vivien Schubert  2 , Laura Vieweg  2 , Sandrine Duplan  1 , Mélanie Marguerettaz  1 , Julie Noëll  1 , Isabelle Pieretti  1 , Manuela Hügelland  2 , Sebastian Kemper  2 , Andi Mainz  2 , Philippe Rott  1 , Monique Royer  1 , Roderich D Süssmuth  2
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The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine

Stéphane Cociancich et al. Nat Chem Biol. 2015 Mar.

Abstract

Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug.

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