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Comment
. 2015 Mar;11(3):131-2.
doi: 10.1038/nrneph.2014.254. Epub 2015 Jan 20.

Clinical trials. Rituximab for maintenance of remission in AAV

Anisha Tanna  1 , Charles Pusey  1
Affiliations
Comment

Clinical trials. Rituximab for maintenance of remission in AAV

Anisha Tanna et al. Nat Rev Nephrol. 2015 Mar.

Abstract

Maintenance therapy for antineutrophil cytoplasmic antibody-associated vasculitis (AAV) should reduce rates of relapse with minimal toxicity. The MAINRITSAN trial—the first randomized controlled trial to compare the efficacies of rituximab and azathioprine in AAV remission maintenance— has demonstrated a superior outcome using rituximab. These data have important implications for the management of AAV.

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  • Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis.
    Guillevin L, Pagnoux C, Karras A, Khouatra C, Aumaître O, Cohen P, Maurier F, Decaux O, Ninet J, Gobert P, Quémeneur T, Blanchard-Delaunay C, Godmer P, Puéchal X, Carron PL, Hatron PY, Limal N, Hamidou M, Ducret M, Daugas E, Papo T, Bonnotte B, Mahr A, Ravaud P, Mouthon L; French Vasculitis Study Group. Guillevin L, et al. N Engl J Med. 2014 Nov 6;371(19):1771-80. doi: 10.1056/NEJMoa1404231. N Engl J Med. 2014. PMID: 25372085 Clinical Trial.

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