The H3Africa policy framework: negotiating fairness in genomics

Jantina de Vries¹, Paulina Tindana², Katherine Littler³, Michèle Ramsay⁴, Charles Rotimi⁵, Akin Abayomi⁶, Nicola Mulder⁷, Bongani M Mayosi⁸

Affiliations

¹ Department of Medicine, University of Cape Town, UCT Centre for Clinical Research, Old Main Building, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa. Electronic address: Jantina.devries@uct.ac.za.
² Navrongo Health Research Centre, Ghana Health Service, PO Box 114, Navrongo, Ghana.
³ Wellcome Trust, Gibbs Building, London, NW1 2BE, UK.
⁴ Division of Human Genetics, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, PO Box 1038, Johannesburg 2000, South Africa.
⁵ Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, Parktown 2193, South Africa.
⁶ Center for Research on Genomics and Global Health, MSC 5635, Bethesda, MD 20892-5635, USA.
⁷ NSB-H3A Biobank, National Health Laboratory Services of South Africa, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, Cape Town 7505, South Africa.
⁸ Institute of Infectious Disease and Molecular Medicine, UCT Faculty of Health Sciences, Observatory 7925, South Africa.

PMID: 25601285
PMCID: PMC4471134
DOI: 10.1016/j.tig.2014.11.004

The H3Africa policy framework: negotiating fairness in genomics

Jantina de Vries et al. Trends Genet. 2015 Mar.

. 2015 Mar;31(3):117-9.

doi: 10.1016/j.tig.2014.11.004. Epub 2015 Jan 15.

Authors

Jantina de Vries¹, Paulina Tindana², Katherine Littler³, Michèle Ramsay⁴, Charles Rotimi⁵, Akin Abayomi⁶, Nicola Mulder⁷, Bongani M Mayosi⁸

Affiliations

¹ Department of Medicine, University of Cape Town, UCT Centre for Clinical Research, Old Main Building, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa. Electronic address: Jantina.devries@uct.ac.za.
² Navrongo Health Research Centre, Ghana Health Service, PO Box 114, Navrongo, Ghana.
³ Wellcome Trust, Gibbs Building, London, NW1 2BE, UK.
⁴ Division of Human Genetics, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, PO Box 1038, Johannesburg 2000, South Africa.
⁵ Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, Parktown 2193, South Africa.
⁶ Center for Research on Genomics and Global Health, MSC 5635, Bethesda, MD 20892-5635, USA.
⁷ NSB-H3A Biobank, National Health Laboratory Services of South Africa, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, Cape Town 7505, South Africa.
⁸ Institute of Infectious Disease and Molecular Medicine, UCT Faculty of Health Sciences, Observatory 7925, South Africa.

PMID: 25601285
PMCID: PMC4471134
DOI: 10.1016/j.tig.2014.11.004

Abstract

Human Heredity and Health in Africa (H3Africa) research seeks to promote fair collaboration between scientists in Africa and those from elsewhere. Here, we outline how concerns over inequality and exploitation led to a policy framework that places a firm focus on African leadership and capacity building as guiding principles for African genomics research.

Keywords: Africa; H3Africa; ethics; fairness; genomics.

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References

1. Rosenberg NA, et al. Genome-wide association studies in diverse populations. Nat. Rev. Genet. 2010;11:356–366. - PMC - PubMed
1. H3Africa Consortium Research capacity. Enabling the genomic revolution in Africa. Science. 2014;344:1346–1348. - PMC - PubMed
1. Need AC, Goldstein DB. Next generation disparities in human genomics: concerns and remedies. Trends Genet. 2009;25:489–494. - PubMed
1. Edwards D, et al. Negotiating research contracts. Creating opportunities for stronger research and innovation systems. Council on Health Research for Development; Geneva: 2014.
1. Emanuel EJ, et al. What makes clinical research in developing countries ethical? The benchmarks of ethical research. J. Infect. Dis. 2004;189:930–937. - PubMed

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The H3Africa policy framework: negotiating fairness in genomics

Affiliations

The H3Africa policy framework: negotiating fairness in genomics

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources