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. 2015 Jan 20;10(1):e0116100.
doi: 10.1371/journal.pone.0116100. eCollection 2015.

Creating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmission

Anatoli Kamali  1 , Matt A Price  2 , Shabir Lakhi  3 , Etienne Karita  4 , Mubiana Inambao  3 , Eduard J Sanders  5 , Omu Anzala  6 , Mary H Latka  7 , Linda-Gail Bekker  8 , Pontiano Kaleebu  1 , Gershim Asiki  1 , Ali Ssetaala  9 , Eugene Ruzagira  1 , Susan Allen  10 , Paul Farmer  10 , Eric Hunter  10 , Gaudensia Mutua  6 , Heeran Makkan  7 , Amanda Tichacek  10 , Ilene K Brill  11 , Pat Fast  12 , Gwynn Stevens  13 , Paramesh Chetty  13 , Pauli N Amornkul  12 , Jill Gilmour  14 ; IAVI Africa HIV Prevention Partnership
Collaborators, Affiliations

Creating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmission

Anatoli Kamali et al. PLoS One. .

Abstract

HIV epidemiology informs prevention trial design and program planning. Nine clinical research centers (CRC) in sub-Saharan Africa conducted HIV observational epidemiology studies in populations at risk for HIV infection as part of an HIV prevention and vaccine trial network. Annual HIV incidence ranged from below 2% to above 10% and varied by CRC and risk group, with rates above 5% observed in Zambian men in an HIV-discordant relationship, Ugandan men from Lake Victoria fishing communities, men who have sex with men, and several cohorts of women. HIV incidence tended to fall after the first three months in the study and over calendar time. Among suspected transmission pairs, 28% of HIV infections were not from the reported partner. Volunteers with high incidence were successfully identified and enrolled into large scale cohort studies. Over a quarter of new cases in couples acquired infection from persons other than the suspected transmitting partner.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Map of the collaborating research centers of the IAVI Africa HIV Prevention Partnership.
MRC/UVRI: Medical Research Council/Uganda Virus Research Institute, IAVI: International AIDS Vaccine Initiative
See this image and copyright information in PMC

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