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Review
. 2015 Jan;18(1):48-54.
doi: 10.3779/j.issn.1009-3419.2015.01.08.

[Tumor microenvironment--the critical element of tumor metastasis]

[Article in Chinese]
Fang Yang  1 , Yan Yu  1
Affiliations
Review

[Tumor microenvironment--the critical element of tumor metastasis]

[Article in Chinese]
Fang Yang et al. Zhongguo Fei Ai Za Zhi. 2015 Jan.

Abstract
in English, Chinese

Metastasis is the main reason for the failure of cancer therapy and the death of patients. The molecular mechanism is complex, involving the change of multi-step, multi-stage and multi-gene. As the survival places of tumor cells, the tumor microenvironment plays a crucial role in tumor metastasis. Therefore, the study of the dynamic relationship between the tumor microenvironment and tumor metastasis, to clarify the molecular mechanisms in the metastasis process is the key point to inhibit the tumor metastasis.

肿瘤转移是癌症治疗失败和患者死亡的主要原因，其分子机制复杂，涉及多步骤、多阶段、多基因的变化。作为肿瘤细胞赖以生存的场所，肿瘤微环境在肿瘤转移过程中起到至关重要的作用。因此，研究肿瘤微环境与肿瘤转移的动态关系，阐明微环境中不同因子在转移过程中的分子机制是抑制肿瘤转移的关键。

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